Georg Reiser Selected Research

Refsum Disease (Refsum's Disease)

3/2016	Brain Lipotoxicity of Phytanic Acid and Very Long-chain Fatty Acids. Harmful Cellular/Mitochondrial Activities in Refsum Disease and X-Linked Adrenoleukodystrophy.
8/2011	Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.
11/2009	The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes.
7/2006	A study of the cytotoxicity of branched-chain phytanic acid with mitochondria and rat brain astrocytes.
6/2006	Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid.
4/2006	Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment.
3/2006	Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria.
2/2005	The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes.
10/2004	In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition.

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Georg Reiser Research Topics

Disease

11	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 10/2008
9	Refsum Disease (Refsum's Disease) 03/2016 - 10/2004
8	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 12/2002
5	Inflammation (Inflammations) 08/2013 - 06/2005
5	Ischemia 02/2006 - 09/2004
4	Brain Injuries (Brain Injury) 01/2021 - 01/2003
4	Neuroinflammatory Diseases 01/2018 - 11/2004
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 11/2009
4	Hypoxia (Hypoxemia) 12/2014 - 07/2003
3	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 03/2016 - 06/2008
3	Astrocytoma (Pilocytic Astrocytoma) 08/2014 - 01/2008
3	Neuroblastoma 03/2013 - 10/2011
3	Peroxisomal Disorders (Peroxisomal Disorder) 08/2011 - 02/2005
3	Brain Ischemia (Cerebral Ischemia) 02/2006 - 01/2003
2	Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile) 09/2017 - 10/2016
2	Ischemic Stroke 01/2017 - 08/2013
2	Inborn Genetic Diseases (Disease, Hereditary) 03/2016 - 10/2004
2	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2015 - 01/2003
2	Parkinson Disease (Parkinson's Disease) 09/2009 - 10/2008
2	Infarction (Infarctions) 02/2008 - 02/2006
2	Lung Diseases (Lung Disease) 07/2007 - 05/2005
2	Neoplasms (Cancer) 08/2006 - 08/2003
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018
1	Huntington Disease (Huntington's Disease) 01/2018
1	Muscular Atrophy (Muscle Atrophy) 01/2018
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2018
1	Nervous System Diseases (Neurological Disorders) 10/2016
1	Starvation 09/2015
1	Osteoarthritis 06/2014
1	Type 2 Diabetes Mellitus (MODY) 06/2014
1	Chondrocalcinosis (Pseudogout) 06/2014
1	Brain Diseases (Brain Disorder) 12/2013
1	Alcoholism (Alcohol Abuse) 03/2013
1	Amyloid Plaque 11/2011
1	Zellweger Syndrome (Zellweger's Syndrome) 08/2011
1	Encephalitis (Encephalitis, Rasmussen) 03/2011

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2002
9	Fatty Acids (Saturated Fatty Acids)IBA 03/2016 - 02/2005
9	Phytanic AcidIBA 03/2016 - 10/2004
6	Proteinase-Activated ReceptorsIBA 12/2014 - 05/2005
5	nardilysinIBA 03/2014 - 03/2009
5	Thrombin FDA Link 10/2008 - 01/2003
3	Purinergic P2Y1 ReceptorsIBA 12/2015 - 01/2008
3	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 09/2004
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2014 - 08/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2013 - 07/2011
3	Serine Proteases (Serine Protease)IBA 08/2013 - 02/2006
3	Metalloendopeptidases (Metalloendopeptidase)IBA 03/2013 - 10/2011
3	Oxygen (Dioxygen)IBA 07/2011 - 09/2004
3	CalciumIBA 04/2011 - 09/2004
3	Peptide Hydrolases (Proteases)FDA Link 03/2009 - 01/2006
3	Adenosine Triphosphate (ATP)IBA 01/2008 - 08/2003
2	Glutamic Acid (Glutamate)FDA Link 09/2017 - 08/2013
2	Phospholipases A2 (Phospholipase A2)IBA 10/2016 - 11/2004
2	Member 1 Subfamily D ATP Binding Cassette TransporterIBA 03/2016 - 05/2015
2	Transcription Factors (Transcription Factor)IBA 08/2013 - 08/2009
2	Neuroprotective AgentsIBA 06/2013 - 02/2008
2	EnzymesIBA 03/2013 - 03/2011
2	Coenzyme A (CoA)IBA 08/2011 - 06/2006
2	pristanic acidIBA 08/2011 - 11/2009
2	Nonesterified Fatty Acids (NEFA)IBA 08/2011 - 07/2011
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 07/2011 - 09/2005
2	Thrombin Receptors (Thrombin Receptor)IBA 10/2008 - 01/2003
2	Adenine NucleotidesIBA 08/2006 - 07/2003
2	NucleotidesIBA 08/2006 - 08/2003
2	Docosahexaenoic AcidsIBA 09/2005 - 11/2004
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021
1	thiamine triphosphorate (TTP)IBA 01/2018
1	polyglutamineIBA 01/2018
1	Superoxide Dismutase-1IBA 01/2018
1	Adenine FDA LinkGeneric 01/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2018
1	CytosineIBA 01/2018
1	Glial Fibrillary Acidic ProteinIBA 01/2018
1	GuanineIBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	Small Heat-Shock ProteinsIBA 01/2018
1	Protein AggregatesIBA 01/2018
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2017
1	N-acetylsphingosineIBA 09/2015
1	StaurosporineIBA 09/2015
1	Crystallins (Crystallin)IBA 09/2015
1	Carrier Proteins (Binding Protein)IBA 05/2015
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2015
1	Cyclin D1IBA 12/2014
1	purinoceptor P2Y6IBA 08/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2014
1	nucleotide pyrophosphataseIBA 06/2014
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 06/2014
1	AntioxidantsIBA 12/2013
1	NexusIBA 10/2013
1	AnticoagulantsIBA 08/2013
1	Protein CIBA 08/2013
1	Ethanol (Ethyl Alcohol)IBA 03/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 11/2011
1	TubulinIBA 10/2011
1	Racemases and Epimerases (Epimerases and Racemases)IBA 08/2011
1	Calcium-Independent Phospholipases A2IBA 03/2011

Therapy/Procedure

3	Therapeutics 12/2013 - 06/2010
1	Thrombectomy 01/2017